Clin. Prof. Psychiatry USC School of Medicine USC School of Medicine, Greenville, SC Greer, South Carolina
Disclosure(s):
Vladimir Maletic, MD, MS: No relevant disclosure to display
Major Depressive Disorder continues to be one of the most frequently diagnosed psychiatric disorders. Numerous antidepressant medications, including both existing monoamine-based drugs and newer fast-acting medications like ketamine, may provide symptom relief for some patients. However, many of these drugs may yield less-than-optimal outcomes. Researchers are now focusing on other potential precursors to depression, to help identify novel targets for pharmacological treatment approaches. In this session, Dr. Vladimir Maletic will review the role of functional brain network dysregulation as a precursor to the onset and exacerbation of mood disorder symptomologies. Dr Maletic will define the structure of major brain networks, as well as the role of monoamines in regulating their function, and the mechanisms by which disruptions to these networks may influence clinical symptoms. In addition, he will discuss how improved patient outcomes may be realized through approaches that optimize monoamine signaling in mood disorders.
Learning Objectives:
Define structure and function of major brain networks and delineate how monoamines regulate their function
Discuss the aberrant relationship between and within major functional brain networks in mood disorders and their relationship with clinical symptoms
Select optimal treatment approaches based on their theoretical ability to normalize functioning of major brain networks in mood disorders
